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KMID : 0043320130360060739
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Archives of Pharmacal Research
2013 Volume.36 No. 6 p.739 ~ p.744
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Aromatic polyketides from a sponge-derived fungus Metarhizium anisopliae mxh-99 and their antitubercular activities
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Kong Xianglan
Ma Xinhua
Xie Yunying
Cai Shengxin
Zhu Tianjiao
Gu Qianqun
Li Dehai
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Abstract
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In our screening for antitubercular agents, five naphtho-γ-pyrones including two new naphtho-γ-pyrones glycosides, indigotides G and H (1 and 2), and two diphenyl ethers were isolated from the extract of a sponge-derived fungus Metarhizium anisopliae mxh-99. Their structures were established on the basis of chemical and spectroscopic evidence. The antitubercular activities of all the compounds were evaluated against Mycobacterium phlei. The known isochaetochromin B2 (6) and ustilaginoidin D (7) exhibited the highest activity with MICs 50.0 μg/mL.
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KEYWORD
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Sponge-derived fungus, Secondary metabolites, Naphtho-γ-pyrones, Diphenyl ethers, Antitubercular activity
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